Using RGD-containing peptide to enhance cell uptake for the detection of furin activity in cells

A new self-assembled nano fluorescence probe was designed and synthesized．The new biocompatible CBT-Cys click reaction was used to cyclize RGD peptide in synthesis method. Using RGD peptide sequence, this probe can targetαvβ３ integrin of cancer cells and react with furin enzyme in cells, resulting in fluorescence“Off-On”．Thus it achieves the ability to target tumor cells for fluorescence imaging.